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Correction: Silina et al. Influence of the Synthesis Scheme of Nanocrystalline Cerium Oxide and Its Concentration on the Biological Activity of Cells Providing Wound Regeneration. <i>Int. J. Mol. Sci.</i> 2023, <i>24</i>, 14501.

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Cerium Phosphate Nanoparticles: Synthesis, Characterization, Biocompatibility, Regenerative Potential, and

Ekaterina V Silina1, Victor A Stupin2, Natalia E Manturova2

  • 1I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.

Molecules (Basel, Switzerland)
|October 16, 2025
PubMed
Summary

Nanoscale cerium phosphate (CePO4) nanoparticles show significant potential for skin regeneration and antioxidant activity. This study developed a method to synthesize these nanoparticles, demonstrating their safety and efficacy in stimulating skin cell proliferation and metabolism.

Keywords:
antioxidantscell proliferationcerium phosphatefibroblastskeratinocytesmesenchymal stem cellsnanoparticlesregenerationrhabdophanewound healing

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Nanotechnology

Background:

  • Cerium phosphate (CePO4) nanoparticles are being explored for various biomedical applications.
  • Understanding the synthesis-structure-property relationship is crucial for optimizing nanomaterial performance.
  • Investigating the effects of nanomaterials on skin cells is vital for wound healing and regenerative medicine.

Purpose of the Study:

  • To synthesize and characterize nanoscale cerium phosphate (CePO4) using different methods.
  • To evaluate the biomedical effects of CePO4 nanoparticles on skin-related cells.
  • To determine the antioxidant properties of CePO4 nanoparticles and their dose-dependent effects.

Main Methods:

  • Cerium(III) orthophosphate synthesis via precipitation and controlled drying/annealing.
  • X-ray diffraction (XRD) for structural analysis (rhabdophane phase identified).
  • Transmission electron microscopy (TEM) for particle size determination (2-10 nm transverse, 20-50 nm longitudinal).
  • In vitro studies on human mesenchymal stem cells (MSCs), keratinocytes, and fibroblasts to assess proliferation, metabolism, and cytotoxicity.
  • Evaluation of antioxidant activity compared to ascorbic acid.

Main Results:

  • Optimized conditions yielded nanosized CePO4 powders with rhabdophane structure.
  • CePO4 nanoparticles demonstrated high safety and regenerative potential for skin cells.
  • Stimulatory effects on MSC proliferation (10^-2 to 10^-3 M) and keratinocyte/fibroblast metabolism (10^-3 to 10^-5 M) were observed.
  • A dose-dependent antioxidant effect (10^-2 to 10^-5 M) exceeding that of ascorbic acid was established.

Conclusions:

  • A novel method for producing CePO4 nanoparticles with beneficial biomedical properties was developed.
  • CePO4 nanoparticles exhibit non-cytotoxicity and promote skin cell regeneration across a broad concentration range.
  • The established antioxidant properties of CePO4 nanoparticles suggest therapeutic potential for skin wound healing.