Efficient Approaches to the Design of Six-Membered Polyazocyclic Compounds-Part 2: Nonaromatic Frameworks

Area of Science:

• Organic Chemistry
• Heterocyclic Chemistry

Background:

• Polyazoaromatic heterocycles are important structural motifs.
• Synthesis of their saturated analogs presents challenges.

Purpose of the Study:

• To review and compare main synthesis strategies for saturated/partially saturated six-membered polyazoaromatic heterocycles.
• To highlight advantages, limitations, and recent advancements in the field.

Main Methods:

• Classical hydrogenation using catalysts and molecular hydrogen.
• Hydrogen transfer techniques for saturation.
• Aromatic framework saturation using non-hydrogen compounds (e.g., hydroboration, dearomatic binding).
• De novo synthesis via coupling of smaller molecules.

Main Results:

• Multiple strategies exist for synthesizing saturated polyazoheterocycles.
• Each method has distinct advantages and limitations.
• Successful synthesis of optically pure products under mild conditions is achievable.

Conclusions:

• Despite challenges, various methods enable synthesis of saturated polyazoheterocycles.
• Recent literature shows progress in achieving complex structures.
• Further research can optimize these methods for broader applications.