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Published on: August 9, 2016
Beyond the Skin: Atopic Dermatitis and Increased Gastric Cancer Risk in Korea
Ho Suk Kang1, Kyeong Min Han2, Joo-Hee Kim3
1Division of Gastroenterology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea.
Background/Objectives:
Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease, but its relationship with gastric cancer (GC) remains unclear. This study aimed to investigate the association between AD and GC using a nationwide Korean database.
Methods:
Using the Korean National Health Insurance Service-National Sample Cohort, we conducted a nested case-control study including 10,174 GC patients and 40,696 matched controls (1:4 by age, sex, income, and region). Overlap propensity score weighting was used to control for confounders. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated via logistic regression.
Results:
AD was significantly associated with an increased risk of GC (adjusted OR = 1.08; 95% CI: 1.01-1.15). Subgroup analyses revealed stronger associations among individuals aged ≥ 65 years (OR = 1.12), men (OR = 1.10), rural residents (OR = 1.14), and those without comorbidities (CCI = 0, OR = 1.15). Higher risks were also observed in participants with non-allergic rhinitis (OR = 1.43) or no asthma (OR = 1.12).
Conclusions:
AD may be associated with an increased risk of GC in the Korean population. These findings may highlight the importance of considering dermatological conditions in the context of systemic cancer risk.
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