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Movement-Based Interventions in Patients Affected by Bone Metastases: Impact on Physical Function and Functional
Giorgia Petrucci1, Agnese Broccolo2, Anna Marchetti3
1Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Rome, Italy.
Cancers
|October 16, 2025
Summary
Structured physical activity and exercise interventions show promise for improving physical function and independence in cancer patients with bone metastases. These programs appear safe and beneficial for daily living activities.
Area of Science:
- Oncology
- Rehabilitation Medicine
- Exercise Science
Background:
- Bone metastases are a frequent complication in advanced cancer, leading to decreased physical function and autonomy.
- Impaired ability to perform Activities of Daily Living (ADLs) significantly impacts patient quality of life.
- Movement-based interventions are being explored as a supportive strategy for these patients.
Purpose of the Study:
- To systematically review the evidence on the impact of physical activity and exercise interventions on functional status and ADL performance in patients with bone metastases.
Main Methods:
- A systematic literature review was conducted across major databases (PubMed, Scopus, Embase, Web of Science, CINAHL) up to March 2025.
- Studies included adults with bone metastases undergoing physical activity interventions targeting function and ADLs.
- Methodological quality was assessed using Joanna Briggs Institute tools.
Main Results:
- Eleven studies (RCTs, quasi-experimental, observational) were included, showing heterogeneity in interventions.
- Most studies reported improvements in physical function (mobility, strength, endurance) and ADL performance.
- Reductions in fatigue were noted, with no serious adverse events.
Conclusions:
- Structured physical activity interventions are safe for patients with bone metastases.
- Exercise programs can enhance physical function and independence in daily living.
- Individualized exercise should be integrated into multidisciplinary cancer care.
