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Aging Accelerates Degradation of Human Neuromuscular Junction Following Peripheral Nerve Injury

Luigi P Gonzales1, Vivian Y Chen1, Amanda Tedesco1

  • 1Department of Orthopaedic Surgery, University of California, Irvine, Irvine, California, USA.

Muscle & Nerve
|October 16, 2025
PubMed
Summary

Older adults experience a more rapid loss of innervated motor endplates (MEPs) after peripheral nerve injury. Despite this, MEP morphology remains similar, suggesting potential for recovery with early surgical intervention in older patients.

Keywords:
agingbrachial plexopathyhuman muscle biopsymotor endplateneuromuscular junction

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