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Patient-Specific Cranio-Facial Porous Titanium Implants: A Multicentric Cohort Study.

Thomas Schouman1,2, Herve Benateau3, Nicolas Le Clerc4

  • 1Service de Chirurgie Maxillo-Faciale, Sorbonne Universite, AP-HP, Hopital Pitie-Salpetriere, Paris, France.

Head & Neck
|October 16, 2025
PubMed
Summary
This summary is machine-generated.

Personalized porous titanium implants (PTIs) show an acceptable benefit-risk profile for craniofacial reconstruction. Careful patient selection is recommended, especially considering anatomical site and prior radiotherapy, to optimize outcomes with these advanced implants.

Keywords:
craniofacialmandiblemidfacepatient‐specific implantstitanium implants

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Area of Science:

  • Biomaterials Science
  • Craniofacial Surgery
  • Medical Device Technology

Background:

  • Personalized porous titanium implants (PTIs) are increasingly utilized for craniofacial reconstruction.
  • Assessing the clinical performance and tolerance of PTIs is crucial for optimizing patient outcomes.

Purpose of the Study:

  • To evaluate the clinical tolerance and performance of personalized porous titanium implants (PTIs) in craniofacial skeletal reconstruction.
  • To identify risk factors associated with PTI failure in a diverse patient cohort.

Main Methods:

  • A retrospective, international multicentric study involving adult patients who received PTIs over a 7-year period.
  • Primary outcome: implant presence without revision. Secondary outcomes: infections, removal, fixation failure, exposure, re-intervention, and adverse events.
  • Risk factor analysis for implant failure, including anatomical site and radiotherapy history.

Main Results:

  • Ninety patients received 97 craniofacial PTIs, with a mean follow-up of 2.46 years. 81.1% of patients retained their implants.
  • Overall success rates varied by site: 97.2% (skull), 78.8% (midface), and 57.1% (mandible).
  • Complications were higher in the mandible group and irradiated patients, with radiotherapy increasing failure risk over 4-fold.

Conclusions:

  • Personalized porous titanium implants (PTIs) demonstrate an acceptable overall benefit-risk profile for craniofacial applications.
  • Patient selection is critical, necessitating consideration of the specific anatomical site and the patient's treatment history, particularly radiotherapy.
  • Further research may refine patient selection criteria to enhance long-term success rates for PTIs.