Related Experiment Video
Updated: Jan 15, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
Published on: January 31, 2025
The role of lipid metabolic interactions in reshaping the tumor microenvironment
Ruyin Yang1,2, Shiyu Liu1,2, Yingqi Bi2
1Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China.
Abstract:
The tumor microenvironment (TME), which encompasses the extracellular matrix, cancer-associated fibroblasts, endothelial cells, pericytes, and immune cells, is intimately connected to tumor development and metastasis. TME is widely heterogeneous, and metabolic interactions among the different components contribute to reshaping TME. Lipid metabolism, referring to lipid uptake, synthesis, transport, and lipolysis, is essential for maintaining cellular homeostasis. The availability of nutrients in the TME constantly changes during tumor progression, and tumor cells must reprogram lipid metabolism to maintain their rapid proliferation, survival, invasion, and metastatic potential. The interactions of lipid metabolism among tumor cells and other cell subtypes reshape the microenvironment into a niche suitable for tumor development. In this review, we present the featured lipid metabolic interactions within the TME of different cancer types and discuss how targeting abnormal lipid metabolic pathways could be a promising strategy for cancer therapeutics.
More Related Videos
Related Concept Videos
The Tumor Microenvironment
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Tumor Immunotherapy
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

