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Updated: Jan 15, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
Evaluation of Proflo-U® Platform for Urine Albumin Measurement in Chronic Kidney Disease Diagnosis: A Comparative
Midde Hari Satyanarayana1, Shivam Mishra2, Debapriya Bandyopadhyay1
1Department of Biochemistry, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Background:
Chronic kidney disease (CKD) presents a global health challenge, requiring efficient assessment tools for effective management. Albuminuria assessment serves as a crucial indicator of CKD diagnosis, stage-classification, and progression risk. However, for the large-scale screening, the current laboratory-based methods lack portability and entail delays. Point-of-care (PoC) solutions like dipsticks offer promise, but sensitivity limitations persist.
Objective:
To address this gap, we evaluated Proflo-U ® , a novel fluorescent-based urine albumin measurement technology with the potential for PoC deployment, with the immunoturbidity-based Beckman Coulter system.
Results:
Our study, based on a blinded comparison of 255 patient samples, revealed a high correlation (R2>0.9) between Proflo-U ® and Beckman Coulter based measurement. Proflo-U ® has been able to demonstrate comparable diagnostic accuracy, with strong sensitivity and specificity across different urine albumin concentration categories. Statistical analyses supported its reliability, and Receiver Operating Characteristic (ROC) analysis highlighted its clinically acceptable diagnostic accuracy.
Conclusion:
Our findings suggest that Proflo-U ® holds potential for mass screening initiatives in resource-limited settings to enable early CKD detection and management.
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