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Updated: Jan 15, 2026

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

805

Risk Assessment Analysis of Type II Diabetes Mellitus and Dyslipidemia with Coronary Artery Stenosis Scoring:

Pradeep Kumar Dabla1, Dharmsheel Shrivastav1, Vimal Mehta2

  • 1Department of Biochemistry, Govind Ballabh Pant Institute of Postgraduate Medical Education & Research, Associated Maulana Azad Medical College, Jawaharlal, Nehru Marg, New Delhi.

EJIFCC
|October 16, 2025
PubMed

Insights

Diabetes significantly worsens coronary artery disease (CAD) severity, indicated by higher Gensini Scores. Managing blood glucose and lipid profiles is crucial for assessing cardiovascular risk in diabetic patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • Diabetes mellitus is a significant risk factor for coronary artery disease (CAD).
  • Diabetic patients often exhibit a higher prevalence of multivessel disease and poorer cardiovascular outcomes.
  • This study investigates the link between lipid profiles, diabetes, and CAD severity.

Purpose of the Study:

  • To explore the relationship between lipid profiles and diabetes in relation to CAD severity.
  • To evaluate the degree of coronary artery stenosis using the Gensini Score (GS).

Main Methods:

  • A cohort of 300 participants was studied: 100 with CAD and diabetes, 100 with CAD without diabetes, and 100 healthy controls.
  • Lipid profiles were quantified, and HbA1c levels were measured.
  • Coronary artery stenosis was assessed using the Gensini Score (GS) from angiographic data.

Main Results:

  • Diabetic CAD patients showed significantly higher Gensini Scores (32.97±22.47) compared to non-diabetic CAD patients (28.70±20.60).
  • Positive correlations were observed between HbA1c, random blood sugar, and triglycerides (TG) with GS.
  • High-density lipoprotein (HDL) levels showed a significant negative correlation with GS.

Conclusions:

  • Lipoprotein levels and diabetic indicators significantly impact CAD severity.
  • Personalized management of diabetes and CAD is essential.
  • Regular monitoring of glucose and lipid levels is recommended for cardiovascular risk assessment.
Abstract

Keywords:
Coronary artery diseaseDiabetes MellitusGensini scoring systemHbA1cLipid profile

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