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Updated: Jan 15, 2026
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
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Integrating a hydrogen-bonded complex as a secondary building unit to construct a multivariate framework for
Xujiao Ma1, Zhong Zhang1, Xianghui Ruan1
1Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, Northeast Normal University Changchun 130012 China Zhugs@nenu.edu.cn gaon320@nenu.edu.cn yangyajie@jlu.edu.cn Yuany101@nenu.edu.cn.
Chemical Science
|October 16, 2025
Summary
Researchers developed a novel hybrid-bonded framework using hydrogen bonds to create a multifunctional porous material. This framework enables precise, sequential drug delivery, significantly enhancing antitumor activity in vivo.
Area of Science:
- Materials Science
- Nanotechnology
- Chemical Engineering
Background:
- Porous organic frameworks (POFs) are functional solids built from organic blocks via covalent bonds.
- Purely covalent POFs exhibit limited interactions with organic molecules, hindering biomedical applications.
- Developing POFs with enhanced molecular interactions is crucial for advanced applications.
Purpose of the Study:
- To engineer a hybrid-bonded framework (F@POF) integrating covalent and hydrogen bonds.
- To enhance drug binding affinity and enable selective drug loading.
- To create a multivariate porous framework for sequential multidrug delivery and improved cancer therapy.
Main Methods:
- Synthesized a hydrogen-bonded complex (HC) of 5-fluorouracil (5-FU) and p-aminobenzoic acid.
- Constructed the F@POF via Schiff base reaction, incorporating both covalent and hydrogen bonds.
- Sequentially immobilized cyclophosphamide (CTX) and methotrexate (MTX) using distinct interaction modalities (van der Waals, hydrogen/π-π).
Main Results:
- Achieved a 19-fold enhanced binding affinity for 5-FU within the F@POF due to multiple hydrogen bonds.
- Successfully created a triple-drug co-doped framework (CMF@POF) with sequential drug immobilization.
- Demonstrated programmable drug release (5-FU > MTX > CTX) and superior antitumor activity in vivo compared to conventional chemotherapy.
Conclusions:
- Hydrogen-bond-guided engineering enables the creation of multifunctional POFs.
- This approach redefines POF design for intelligent multidrug delivery systems.
- Offers a transformative strategy for optimizing combination chemotherapy with enhanced efficacy.
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