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The Oral Microbiota

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...

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Updated: Jun 18, 2026

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

Published on: January 25, 2011

Meta-omics reveals subgingival plaque reconstruction dynamics.

Fangjie Zhou^1,2, Yajie Wu^1,2, Biao Ren^1,3

¹State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Journal of Oral Microbiology

|October 16, 2025

Summary

This summary is machine-generated.

The subgingival microbiome recovers within a year after disruption, with specific bacteria and functions sequentially re-establishing. This study reveals microbial interactions driving this periodontal health recovery process.

Keywords:

Oral microbiota dynamics metagenome reconstruction subgingival plaque

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Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

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Published on: December 31, 2017

Area of Science:

Microbiology
Periodontology
Systems Biology

Background:

Subgingival microbiome homeostasis is vital for periodontal health.
Microbiota community dynamics after disruption are not well understood.

Purpose of the Study:

Investigate subgingival microbiota reassembly dynamics post-disruption.
Identify core taxa, functions, and driving forces in recovery.
Understand periodontal health maintenance through microbiome stability.

Main Methods:

Collected 339 subgingival plaque samples over 1 year from periodontally healthy individuals.
Utilized full-length 16S rRNA sequencing for all samples.
Performed metagenomic sequencing on 30 selected samples.

Main Results:

Disturbed microbiota reverted to baseline stability within one year.
Homogeneous selection drove convergent community structure.
Key taxa (e.g., *Pseudomonas fluorescens*, *Haemophilus parainfluenzae*, *Capnocytophaga spp.*) and functions (e.g., metabolism, biofilm formation) sequentially reconstructed.
Internal microbial interactions drove community assembly.

Conclusions:

Clarified species and functional dynamics during subgingival microbiota reconstruction.
Mapped time-directed networks of stage-specific bacteria.
Provided a theoretical basis for targeted microbiome regulation in periodontal health.