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The Features of Vessel Densities and Hemorheological Parameters in Patients With Central Retinal Vein Occlusion: A

Xuan Li1, Shuyue Huang2, Ziyang Chen3

  • 1Department of Ophthalmology, Eye Hospital China Academy of Chinese Medical Sciences, Beijing 100040, China.

Journal of Ophthalmology
|October 16, 2025
PubMed

Insights

Central retinal vein occlusion (CRVO) patients exhibit elevated blood viscosity and erythrocyte aggregation, indicating thrombophilia. Reduced blood vessel density in the optic disc significantly impacts visual acuity in CRVO eyes.

Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Hematology

Background:

  • Central Retinal Vein Occlusion (CRVO) is a significant cause of vision loss.
  • Understanding the interplay between hemorheological parameters and vascular changes in CRVO is crucial for effective management.

Purpose of the Study:

  • To investigate alterations in vessel densities (VDs) and hemorheological parameters in CRVO patients.
  • To correlate these changes with visual acuity and structural parameters.

Main Methods:

  • A prospective randomized case-control study involving 80 CRVO patients and 80 controls.
  • Optical coherence tomography angiography was used to measure VDs and structural parameters.
  • Hemorheological parameters, including whole blood viscosity and erythrocyte aggregation index, were assessed.

Main Results:

  • CRVO patients showed significantly higher low shear rate-whole blood viscosity (LSR-WBV), high shear rate-whole blood viscosity (HSR-WBV), and erythrocyte aggregation index (AI) compared to controls.
  • CRVO eyes presented with lower best-corrected visual acuity (BCVA), reduced optic disc and macular VD, and altered structural parameters.
  • Unaffected eyes of CRVO patients also exhibited decreased VD in the optic disc and deep capillary plexus.
  • BCVA in CRVO eyes was strongly correlated with optic disc VD (p=0.001, r=-0.391).

Conclusions:

  • CRVO patients demonstrate increased thrombophilia and hemorheological abnormalities.
  • Blood perfusion is significantly compromised in the optic disc and macula of CRVO eyes, and partially reduced in unaffected eyes.
  • Optic disc vessel density is a critical factor influencing visual acuity and may represent a significant risk factor in CRVO.

Keywords:
central retinal vein occlusionhemorheologyoptic nerveoptical coherence tomography angiographyvessel density

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