Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

18.4K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
18.4K
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

4.0K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RNA Sequencing on Muscle Biopsies from Exertional Rhabdomyolysis Patients Revealed Down-Regulation of Mitochondrial Function and Enhancement of Extracellular Matrix Composition.

Genes·2025
Same author

Exercise collapse associated with sickle cell trait: from consensus to confusion.

British journal of sports medicine·2025
Same author

Avatar-Based Health Education: Applying Self-determination Theory to Promote Preventative Care in U.S. Military Service Members.

Military medicine·2025
Same author

Multidisciplinary Case Review Committee: Comprehensive Referral Source for Evaluation and Treatment of High-Risk Exertional Injuries Fostering Safe and Expeditious Return to Duty Decisions.

Military medicine·2025
Same author

Label Accuracy and Quality of Select Weight-Loss Dietary Supplements Sold on or near US Military Bases.

Nutrients·2025
Same author

Is Greener Better? Quantifying the Impact of a Nature Walk on Stress Reduction Using HRV and Saliva Cortisol Biomarkers.

International journal of environmental research and public health·2024
Same journal

A Case of Malan Syndrome With Pulmonary Artery Dilatation due to a Novel Frameshift Variant in Exon 2 of the <i>NFIX</i> Gene.

Case reports in genetics·2026
Same journal

A Case of Nonimmune Hydrops Fetalis With a Duct-Dependent Systemic Circulation and a Novel Mutation of Kabuki Syndrome.

Case reports in genetics·2026
Same journal

A Case of Pallister-Killian Syndrome in a Newborn.

Case reports in genetics·2026
Same journal

A Case Highlighting the Importance of Timely Intervention for a Male With AZFb + c Microdeletion.

Case reports in genetics·2026
Same journal

Clinical Heterogeneity of a <i>TP53</i> Variant in a Consanguineous Omani Family: A Case Report Featuring a Homozygous Pathogenic Variant.

Case reports in genetics·2026
Same journal

Prolonged Survival With Homozygous Deletion of Exon 9 in Perlman Syndrome: A Case Report.

Case reports in genetics·2026
See all related articles

Related Experiment Video

Updated: Jan 15, 2026

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases
08:12

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Published on: October 4, 2024

2.4K

Mitochondrial Dysfunction in Sickle Cell Trait Carriers With Exertional Collapse.

Kristen A Cofer1,2, Liam Friel1,2, Mingqiang Ren1,2

  • 1Consortium for Health and Military Performance, Department of Military and Emergency Medicine, F. Edward Hébert School of Medicine, Uniformed Services University, Bethesda, Maryland, USA.

Case Reports in Genetics
|October 16, 2025
PubMed
Summary
This summary is machine-generated.

Sickle cell trait (SCT) carriers experiencing exertional collapse (ECAST) may have underlying mitochondrial dysfunction. Genetic mutations in POLG and RRM2B were identified in two cases, highlighting a potential link to exertional injuries.

Area of Science:

  • Exercise physiology
  • Genetics
  • Mitochondrial biology

Background:

Keywords:
exertional injurymitochondrial depletionpathogenic variantrhabdomyolysissickle cell trait

More Related Videos

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry
06:53

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry

Published on: November 23, 2011

37.6K
Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

12.2K

Related Experiment Videos

Last Updated: Jan 15, 2026

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases
08:12

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Published on: October 4, 2024

2.4K
Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry
06:53

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry

Published on: November 23, 2011

37.6K
Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

12.2K
  • Sickle cell trait (SCT) is linked to exertional rhabdomyolysis and sudden death in athletes and Service Members (SMs).
  • Exercise collapse associated with SCT (ECAST) is an under-recognized condition with varied presentations, from muscle pain to collapse.
  • The underlying mechanisms of ECAST in SCT carriers are not fully understood.