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Ischemic core or reversible tissue? Limits of a single ADC threshold in predicting DWI reversal after rapid and

Teresa Perillo1, Liam O'Halloran2

  • 1Department of Radiology, CTO Hospital, Azienda Ospedaliera dei Colli, Naples, Italy. tperillo3@gmail.com.

European Radiology
|October 16, 2025
PubMed
Abstract

No abstract available in PubMed .

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...