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Utility of CHA2DS2-VASc Score in Predicting Contrast-induced Nephropathy in Patients with Acute Myocardial Infarction

Ramya R Bhat1, Ashwin Kulkarni2, Anupama V Hegde3

  • 1Junior Resident, Department of General Medicine, Ramaiah Medical College, Bengaluru, Karnataka, India.

The Journal of the Association of Physicians of India
|October 16, 2025
PubMed

Insights

The CHA2DS2-VASc score can predict contrast-induced nephropathy (CIN) in patients undergoing percutaneous coronary intervention (PCI). A score greater than 2 indicates a higher risk of developing CIN, aiding in risk stratification for this kidney impairment.

Area of Science:

  • Nephrology
  • Cardiology
  • Interventional Cardiology

Background:

  • Contrast-induced nephropathy (CIN) is a kidney impairment following contrast agent injection.
  • Patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) are at risk for CIN.
  • Current methods for predicting CIN lack high accuracy.

Purpose of the Study:

  • To validate the CHA2DS2-VASc score for predicting CIN in patients undergoing PCI.
  • To assess the predictive capability of the CHA2DS2-VASc score in this patient population.

Main Methods:

  • A cross-sectional study of 182 patients with ACS undergoing PCI.
  • Calculation of CHA2DS2-VASc scores for all patients.
  • Receiver operating characteristic (ROC) curve analysis to determine optimal cutoff values for predicting CIN.

Main Results:

  • The incidence of CIN was 14.3%.
  • The CHA2DS2-VASc score demonstrated a high predictive value (ROC value = 0.896).
  • A CHA2DS2-VASc score >2 was associated with a statistically significant increase in CIN incidence.

Conclusions:

  • The CHA2DS2-VASc score is a valuable tool for predicting contrast nephropathy in patients with acute myocardial infarction undergoing angiography.
  • Elevated CHA2DS2-VASc scores (>2) identify patients at higher risk for CIN post-PCI.
Abstract

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