Mortality in dermatology: A retrospective study of cause and course

Background Certain dermatological disorders can result in major morbidity and mortality. There are few studies worldwide regarding mortality in dermatology, with a paucity of data on the epidemiological and aetiological profile of sepsis in dermatology patients, necessitating further research and awareness. We aimed to bridge this gap by studying the mortality associated with dermatological diseases at a tertiary care hospital in southern India. Methods Inpatient records of all patients admitted over a period of 5 years (2018-2022) with a dermatological disease and systemic complications resulting in mortality were reviewed. Details regarding the nature of the disorder, disease characteristics, investigations, treatment, and course of hospitalization were collected and analyzed. Results Thirteen patients with dermatological disease-related mortality were included in the study. Mortality was highest in the 4th-6th decade age group. Cutaneous adverse drug reactions accounted for the highest mortality. Septic shock was the most common cause of death in these patients. Conclusion Cutaneous adverse drug reactions are a common cause of mortality among dermatology inpatients. Sepsis and multiorgan dysfunction are important complications in these patients, highlighting the role of strict aseptic precautions, barrier nursing and multidisciplinary care in patients with extensive skin involvement.