Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dihybrid Crosses01:18

Dihybrid Crosses

80.8K
Overview
80.8K
Crossing Over01:30

Crossing Over

6.1K
Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I,...
6.1K
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

6.6K
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
6.6K
Homologous Recombination02:31

Homologous Recombination

62.6K
The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
62.6K
Gene Conversion02:08

Gene Conversion

10.6K
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
10.6K
Overview of Transposition and Recombination02:13

Overview of Transposition and Recombination

18.8K
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
18.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Explainable artificial intelligence models for accurate physical activity prediction using wearable device data.

Journal of science and medicine in sport·2026
Same author

CHARMM-GUI Quick Bilayer: Simple and Intuitive One-Stop Membrane Bilayer Builder.

Journal of molecular biology·2026
Same author

Crossover control: A key to unlocking genetic diversity in plant breeding.

Journal of integrative plant biology·2026
Same author

Group-wise Compression and Summarization via LLM-based Ensemble for Chest X-ray Report Generation.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

COmapper: high-resolution mapping of meiotic crossovers by long-read sequencing in Arabidopsis.

The New phytologist·2025
Same author

Regenerative effect of human cell-derived BMP-2 cultured within a collagen bone graft in a rat calvaria defect model.

Journal of applied biomaterials & functional materials·2025

Related Experiment Video

Updated: Jan 14, 2026

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR
06:18

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR

Published on: July 11, 2025

806

Meiotic recombination and advances in quantitative trait locus mapping.

Dohwan Byun1, Sang-Jun Park1, Kyuha Choi1

  • 1Department of Life Sciences, Pohang University of Science and Technology, Pohang, South Korea.

Current Opinion in Plant Biology
|October 16, 2025
PubMed
Summary

Unlocking plant meiotic crossovers boosts genetic diversity for crop improvement. Strategies to increase crossovers enhance quantitative trait loci mapping and accelerate breeding programs.

More Related Videos

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
10:08

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

17.6K
Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction
08:01

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction

Published on: November 20, 2018

9.7K

Related Experiment Videos

Last Updated: Jan 14, 2026

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR
06:18

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR

Published on: July 11, 2025

806
Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
10:08

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

17.6K
Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction
08:01

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction

Published on: November 20, 2018

9.7K

Area of Science:

  • Plant genetics
  • Molecular biology
  • Agricultural science

Background:

  • Meiotic crossovers are crucial for shuffling genetic variation in plants, but their limited number and distribution restrict crop improvement.
  • Crossovers are rare in pericentromeric regions, hindering fine mapping of quantitative trait loci (QTLs).

Purpose of the Study:

  • To review factors regulating meiotic crossover numbers and distribution.
  • To explore genetic strategies for increasing crossovers in plants.
  • To consider the implications of elevated crossover frequency for plant breeding and QTL analysis.

Main Methods:

  • Review of recent findings on pro- and anti-crossover factors.
  • Analysis of epigenetic mechanisms suppressing pericentromeric recombination.
  • Exploration of genetic strategies to manipulate crossover regulators.

Main Results:

  • Identification of key pro- and anti-crossover factors influencing recombination.
  • Understanding of epigenetic mechanisms that suppress crossovers in heterochromatic regions.
  • Proposed genetic strategies to maximize crossovers across the genome.

Conclusions:

  • Manipulating meiotic crossovers can enhance genetic variation for crop improvement.
  • Increased crossover frequency improves QTL mapping resolution.
  • Elevating crossovers accelerates breeding cycles and crop development.