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Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
Published on: May 16, 2017
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Viral interference of nucleocytoplasmic transport
Chia-Yu Chien1, George W Mobbs1, Joel Ehrenkranz1
1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA.
The Journal of Biological Chemistry
|October 16, 2025
Summary
Viruses exploit cell structures like the nuclear envelope (NE) and nuclear pore complexes (NPCs) to replicate. This review explores how viruses manipulate NPCs and transport to evade immunity and boost viral production.
Area of Science:
- Cell biology
- Virology
- Molecular biology
Background:
- Eukaryotic cells possess a nuclear envelope (NE) with nuclear pore complexes (NPCs) that regulate molecular transport.
- This compartmentalization is crucial for gene expression and cellular functions.
- Viruses have developed strategies to interfere with NE and NPC functions.
Purpose of the Study:
- To review how viruses interact with the NE and NPCs.
- To examine viral hijacking of nucleocytoplasmic transport.
- To understand how viruses disable host immune responses.
Main Methods:
- Literature review of viral strategies targeting the NE and NPCs.
- Analysis of viral manipulation of nucleocytoplasmic transport pathways.
- Examination of viral evasion mechanisms against host immunity.
Main Results:
- Viruses remodel NPC architecture to facilitate their replication.
- Viral strategies involve hijacking the NPC for nucleocytoplasmic transport.
- Viruses actively disable host innate immune responses via NE/NPC manipulation.
Conclusions:
- Viral exploitation of the NE and NPCs is a key factor in viral replication.
- Understanding these interactions can reveal new antiviral targets.
- Targeting viral manipulation of nuclear transport offers therapeutic potential.
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