Related Experiment Video

Updated: Jan 14, 2026

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes
11:48

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes

Published on: May 31, 2018

12.0K

Substance P Expands Proinflammatory, IL-31-Secreting M2 Macrophages in Human Skin Ex Vivo through Neurokinin-1

Sofia M Perez1, Jennifer Gherardini2, Mounika Vattigunta1

  • 1Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, Miami Itch Center, University of Miami Miller School of Medicine, Miami, Florida, USA.

The Journal of Investigative Dermatology
|October 16, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Atopic dermatitisHuman skinInflammationMacrophageNeuromediators

More Related Videos

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
08:49

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

12.8K
Separation of Rat Epidermis and Dermis with Thermolysin to Detect Site-Specific Inflammatory mRNA and Protein
08:45

Separation of Rat Epidermis and Dermis with Thermolysin to Detect Site-Specific Inflammatory mRNA and Protein

Published on: September 29, 2021

5.8K

Related Experiment Videos

Last Updated: Jan 14, 2026

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes
11:48

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes

Published on: May 31, 2018

12.0K
Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
08:49

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

12.8K
Separation of Rat Epidermis and Dermis with Thermolysin to Detect Site-Specific Inflammatory mRNA and Protein
08:45

Separation of Rat Epidermis and Dermis with Thermolysin to Detect Site-Specific Inflammatory mRNA and Protein

Published on: September 29, 2021

5.8K

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

15.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.9K
Inflammation01:38

Inflammation

61.6K
Overview
61.6K
IP3/DAG Signaling Pathway01:11

IP3/DAG Signaling Pathway

14.2K
Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
14.2K

Articles linked to this work by shared authors, journal, and citation graph.

Corticosteroid-Associated Adverse Events in Chronic Spontaneous Urticaria: A US Claims Data Study.

Dermatology and therapy·2026

Itch Relief and Quality-of-Life Improvement with Abrocitinib and Dupilumab in Patients with Moderate-to-Severe Atopic Dermatitis: A Post Hoc Analysis of JADE COMPARE and JADE DARE.

American journal of clinical dermatology·2026

Sphenopalatine Ganglion Radiofrequency Ablation for Severe Facial Rosacea Manifestations.

Pain practice : the official journal of World Institute of Pain·2026

Efficacy of Remibrutinib versus Dupilumab at Early Timepoints in Chronic Spontaneous Urticaria: US Phase 3b Study Design (RECLAIM).

Dermatology and therapy·2026

Dupilumab subgroup responder analysis: a post hoc analysis from LIBERTY PRIME and PRIME2 in prurigo nodularis.

The Journal of dermatological treatment·2026

Epigenetic Modification in Preclinical and Clinical Dermatological Itch Conditions.

European journal of pain (London, England)·2026

The AhR-TFAP2A Axis Regulates Melanosome Transport by Directly Targeting Myosin Va and Mlph.

The Journal of investigative dermatology·2026

Differential BET protein recruitment to IL6 and IL8 promoters and suppression of inflammatory and cell cycle genes by BET inhibitor in keratinocytes.

The Journal of investigative dermatology·2026

Lesional hair lipidomic signatures reveal ARA-LTB4 pathway activation and NETs formation in hidradenitis suppurativa.

The Journal of investigative dermatology·2026

Contact hypersensitivity promotes hair regeneration through SPP1-secreting macrophages.

The Journal of investigative dermatology·2026

Blood proteomics links systemic inflammation with early atherosclerosis in moderate-to-severe atopic dermatitis.

The Journal of investigative dermatology·2026

Defensins Mediate Skin Inflammation and Itch in Psoriasis.

The Journal of investigative dermatology·2026

A Pragmatic Approach to Investigating Nosocomial Acquisition of Rare and Emerging Molds.

Medical mycology·2026

Rapid FTIR-based serotyping of Streptococcus pneumoniae using the IR Biotyper: a comparative study against WGS and PCR-hybridization for clinical algorithm integration.

Microbiology spectrum·2026

Synergistic activity of colistin and stilbenoids against Pseudomonas aeruginosa clinical isolates.

Microbiology spectrum·2026

MeCP2 MBD-ID module: a unified DNA/RNA binding interface disrupted in Rett syndrome.

Nucleic acids research·2026

Neutrophils promote endothelial cell activation in pediatric Mycoplasma pneumoniae pneumonia.

JCI insight·2026

Proton Pump Inhibitor Use Increases the Risk of Recurrent Clostridioides difficile Infection: A Bias-Controlled Nationwide Real-World Data Study.

Gut and liver·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us