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Typical and atypical clinical presentations
Valentina Damato1, Francesca Beretta1
1Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.
International Review of Neurobiology
|October 16, 2025
Summary
Myasthenia gravis (MG) presents with fatigability and fluctuating muscle weakness. Understanding its varied clinical presentations, including ocular-only and generalized forms, is crucial for diagnosis and treatment.
Area of Science:
- Neurology
- Clinical Medicine
Background:
- Myasthenia gravis (MG) is a classic neuromuscular junction disorder.
- Key symptoms include fatigability and fluctuating muscle weakness.
Purpose of the Study:
- To detail the diverse clinical presentations of myasthenia gravis.
- To emphasize the importance of recognizing specific muscle group involvement and atypical forms.
Main Methods:
- Review of clinical hallmarks and patterns of weakness in MG.
- Analysis of anamnestic cues and diagnostic considerations.
Main Results:
- MG can be localized to extraocular muscles or generalized, impacting therapeutic and prognostic outcomes.
- Familiarity with common, uncommon, and atypical MG presentations is essential for clinicians.
Conclusions:
- Accurate identification of MG subtypes based on clinical presentation and muscle distribution is vital.
- Awareness of myasthenic crisis and atypical presentations aids in differential diagnosis.
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