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Related Experiment Video

Updated: Jan 14, 2026

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

Clinical outcome measures.

Alexandria Matic¹, Yvonne Campman², Martijn Rudolf Tannemaat²

¹Division of Neurology, Department of Medicine, Prosserman Family Neuromuscular Clinic, University of Toronto, Toronto, ON, Canada.

International Review of Neurobiology

|October 16, 2025

Summary

Measuring myasthenia gravis (MG) severity is difficult due to fluctuating muscle weakness. This review covers various outcome measures for assessing MG signs, symptoms, quality of life, and using electrophysiology and serology.

Keywords:

Myasthenia gravis clinical neurophysiology disease severity outcome measures

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Area of Science:

Neurology
Clinical Trials

Background:

Myasthenia gravis (MG) presents with fluctuating skeletal muscle weakness, complicating accurate disease severity assessment.
A variety of outcome measures exist, ranging from clinical examinations to patient-reported outcomes and quality-of-life assessments.

Purpose of the Study:

To review established and novel outcome measures for assessing myasthenia gravis disease severity.
To evaluate the utility of quality of life assessments in myasthenia gravis research.
To discuss the role of electrophysiology and serology as surrogate outcome measures in myasthenia gravis studies.

Main Methods:

Literature review of outcome measures for myasthenia gravis.
Analysis of different assessment types: examination-based, patient-reported, and combined measures.
Inclusion of quality of life, electrophysiology, and serology as outcome assessment domains.

Main Results:

Multiple validated instruments exist for measuring myasthenia gravis signs and symptoms.
Patient-reported outcomes and quality of life measures provide valuable insights into the patient experience.
Electrophysiology and serology show potential as surrogate markers but require further validation in specific contexts.

Conclusions:

Selecting appropriate outcome measures is crucial for accurately evaluating myasthenia gravis progression and treatment efficacy.
A comprehensive assessment strategy should integrate clinical, patient-reported, and potentially surrogate outcome measures.
Continued research is needed to refine and validate outcome measures for myasthenia gravis.