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Traditional treatments and different geographical approaches
Valeria L Salutto1, Ha Young Shin2, Gabriel Cea3
1Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina; Centro de Asistencia, Docencia e Investigación en Miastenia Gravis, Buenos Aires, Argentina.
International Review of Neurobiology
|October 16, 2025
Summary
This review compares myasthenia gravis (MG) treatments, including traditional and novel therapies. It highlights the importance of considering individual patient factors and guideline variations for effective MG management.
Area of Science:
- Neurology
- Immunology
- Pharmacology
Background:
- Myasthenia gravis (MG) management involves symptomatic and immunosuppressive/immunomodulatory treatments.
- Treatment selection depends on efficacy, disease subtypes, activity, side effects, and comorbidities.
Purpose of the Study:
- To review and compare existing and novel therapies for myasthenia gravis.
- To analyze and contrast international and national management guidelines and regional approaches.
Main Methods:
- Comparative review of symptomatic treatments.
- Analysis of immunosuppressive and immunomodulatory therapies.
- Examination of various MG management guidelines and consensus statements.
Main Results:
- Traditional treatments like pyridostigmine and steroids are common starting points.
- Variability exists in guidelines regarding glucocorticoids and non-steroidal immunosuppressants.
- Novel therapeutics should complement, not replace, established interventions.
Conclusions:
- Personalized treatment strategies are crucial for myasthenia gravis.
- Understanding guideline differences is essential for optimal patient care.
- Older interventions remain vital in the comprehensive treatment of MG.
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