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Updated: Jan 14, 2026

Orthotopic Hind Limb Transplantation in the Mouse

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

Amputation as an Alternative.

Drishti Dhawan¹, Barry I Rosenblum¹

¹Division of Podiatric Medicine and Surgery, Beth Israel Deaconess Medical Center, Boston, MI, USA.

Clinics in Podiatric Medicine and Surgery

|October 16, 2025

Summary

Diabetic limb salvage aims to preserve foot function, but strategic amputation can offer better outcomes when salvage fails. This approach prioritizes patient recovery and quality of life over prolonged, unsuccessful limb-saving attempts.

Keywords:

Amputation Amputation rehabilitation Diabetes Diabetic foot osteomyelitis Diabetic foot ulcers Limb salvage Lower extremity amputation Revascularization

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Area of Science:

Podiatry
Diabetology
Vascular Surgery

Background:

Diabetes-related pedal complications necessitate complex management strategies.
Limb salvage is the primary goal, focusing on preserving mobility and function.
Amputation is considered when limb salvage attempts fail or pose significant risks.

Purpose of the Study:

To explore the decision-making process between diabetic limb salvage and amputation.
To analyze clinical, psychological, and socioeconomic factors influencing this choice.
To reframe amputation as a potentially beneficial strategic option.

Main Methods:

Review of clinical guidelines and outcomes data for limb salvage versus amputation.
Analysis of patient-reported outcomes, including quality of life and functional recovery.
Consideration of psychological and socioeconomic impacts on patients.

Main Results:

Limb salvage techniques include revascularization, reconstruction, and debridement.
Strategic amputation can lead to faster recovery and improved functionality compared to failed salvage.
Decision-making involves balancing potential benefits against risks and patient-specific factors.

Conclusions:

Amputation should not be viewed solely as a failure in managing diabetic foot complications.
Strategic amputation can optimize patient outcomes, including faster recovery and enhanced quality of life.
A comprehensive evaluation of clinical, psychological, and socioeconomic factors is crucial for optimal patient management.