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Surgical outcome of cerebral amyloid angiopathy-related cerebral hemorrhage-A multicenter comparative study
K Chikh1, J Burel2, A Nikiema3
1Université de Rouen Normandie, Inserm U1245 and University Hospital of Rouen, Department of Neurology, 76000 Rouen, France.
Insights
Surgery for intracerebral hemorrhages (ICH) linked to cerebral amyloid angiopathy (CAA) may not increase postoperative rebleeding risk. This study found similar rebleeding rates in CAA-related ICH versus non-CAA ICH patients after surgery.
Area of Science:
- Neurosurgery
- Neurology
- Radiology
Background:
- Cerebral amyloid angiopathy (CAA) diagnosis is rising due to an aging population.
- Surgery for lobar intracerebral hemorrhages (ICH) in CAA patients is thought to have a high rebleeding risk.
- The Edinburgh criteria on CT scans aid in CAA diagnosis.
Purpose of the Study:
- To compare the postoperative rebleeding risk of CAA-related ICH with non-CAA-related ICH.
- To evaluate surgical outcomes in patients with lobar ICH and suspected CAA.
Main Methods:
- A retrospective study included 140 patients with spontaneous lobar ICH who underwent surgery (2008-2022).
- A neuroradiologist assessed CAA using Edinburgh/Boston criteria on pre-operative CT scans.
- Postoperative rebleeding was evaluated on CT scans within 48 hours.
Main Results:
- Postoperative rebleeding rates at 24-48 hours did not significantly differ between CAA (13%) and non-CAA (15%) groups.
- Rates of rebleeding with clinical deterioration were similar (9% vs. 6%).
- Mortality and modified Rankin Scale scores at three months post-discharge showed no significant differences between groups.
Conclusions:
- No significant difference in postoperative rebleeding rates was found between CAA-related ICH and other causes of ICH.
- Surgical intervention for ICH associated with CAA does not appear to carry a higher rebleeding risk.
Background:
Surgery for lobar intracerebral hemorrhages (ICH) associated with cerebral amyloid angiopathy (CAA) is believed to carry a high risk of postoperative rebleeding. The diagnosis of CAA is increasing with an aging population and external validation of the Edinburgh criteria on computed tomography (CT) scans. The aim of this study was to assess the postoperative risk of CAA-related ICH compared to non-CAA-related ICH.
Methods:
We included patients admitted between 2008 and 2022 for spontaneous lobar ICH who underwent surgery at three university hospitals. A single-blinded neuroradiologist analyzed the Edinburgh criteria on the initial CT scan before surgery and assessed rebleeding on a repeat CT scan performed within 48hours after surgery. Patients were classified into the "CAA group" according to the Edinburgh or Boston criteria, and into the "non-CAA group" if they had another cause of ICH.
Results:
A total of 140 patients were included, with 23 in the CAA group, 93 in the non-CAA group, and 24 in the undetermined group. The postoperative rebleeding rate at 24-48hours did not differ significantly between groups (13% in the CAA group vs. 15% in the non-CAA group, P>0.99). The overall rate of rebleeding associated with clinical deterioration did not differ between groups (9% in the CAA group vs. 6% in the non-CAA group, P=0.66). The overall mortality rate during the acute phase did not significantly differ between groups (4% in the CAA group vs. 12% in the non-CAA group, P=0.46). The modified Rankin scale score three months after discharge ranged from 0 to 3 for 63% of CAA patients compared to 53% of non-CAA patients, with no significant difference (P=0.59).
Conclusion:
We did not find a significant difference in the postoperative rebleeding rate after ICH associated with CAA compared to other causes.
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