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Drug Dosing: Infants and Children01:29

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Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
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Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
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Fluid Therapy in the Neonatal or Pediatric Patient.

Jamie M Burkitt-Creedon1, Karen Michelle Vernau1

  • 1Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, 1 Shields Avenue, Davis, CA 95616, USA.

The Veterinary Clinics of North America. Small Animal Practice
|October 16, 2025
PubMed
Summary

This review covers fluid therapy for young animals, highlighting their unique needs. Proper fluid and electrolyte management is crucial for survival in puppies and kittens.

Keywords:
DehydrationHypovolemiaNeonatal fluid requirementsNeonatal fluid therapyPediatric veterinary medicineShock fluid therapyTube feeding kittens

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Area of Science:

  • Veterinary Medicine
  • Pediatric Animal Care

Background:

  • Neonatal and pediatric animals, including puppies and kittens, have distinct physiological requirements.
  • Their fluid and electrolyte needs differ significantly from adult animals.

Purpose of the Study:

  • To review essential fluid therapy principles for puppies and kittens.
  • To emphasize tailored strategies for this vulnerable population.

Main Methods:

  • Review of current literature on pediatric fluid therapy.
  • Discussion of clinical signs, diagnostics, and administration routes.
  • Outline of maintenance rates and rehydration protocols.

Main Results:

  • Puppies and kittens have higher and distinct fluid and electrolyte requirements.
  • Enteral administration is preferred, with IV and IO for severe cases.
  • Rapid and appropriate fluid replacement is vital for dehydration, ongoing losses, and shock.

Conclusions:

  • Close monitoring and individualized treatment plans are necessary.
  • Effective fluid management significantly improves survival and health outcomes in young animals.