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Chronic kidney disease is associated with increased risk of sudden cardiac death

Yalan Li1,2, Ruchao Jiang1, Chenxi Ouyang1

  • 1Clinical Research Center, The Third Xiangya Hospital, Central South University, Changsha, China.

Nature Communications
|October 16, 2025
PubMed

Insights

Chronic kidney disease (CKD) patients face a higher risk of sudden cardiac death (SCD). This risk increases with CKD severity, highlighting the need for integrated cardiovascular and kidney care.

Area of Science:

  • Nephrology
  • Cardiology
  • Proteomics

Background:

  • Chronic kidney disease (CKD) patients are at elevated risk for cardiovascular disease (CVD).
  • The specific long-term risk of sudden cardiac death (SCD) in CKD patients remains poorly understood.
  • CKD involves traditional risk factors, kidney-specific issues, and comorbidities contributing to CVD risk.

Purpose of the Study:

  • To investigate the association between CKD and the long-term risk of SCD.
  • To identify potential protein biomarkers linking CKD and SCD risk.

Main Methods:

  • Utilized UK Biobank and Changsha cohorts to analyze CKD and SCD incidence.
  • Conducted proteomic analyses on UK Biobank and Framingham Offspring Cohort data.
  • Examined the association between CKD stages and SCD risk.

Main Results:

  • CKD is significantly associated with an increased long-term risk of SCD.
  • Patients with early-stage and advanced CKD demonstrated a heightened risk of SCD.
  • Identified five candidate proteins (NTproBNP, ANGPT2, FGF23, DTNB, SEPTIN8) associated with SCD risk in CKD patients.

Conclusions:

  • CKD patients have a substantially increased long-term risk of SCD.
  • Effective management strategies must address both cardiovascular health and renal function in CKD.
  • The identified proteins may serve as potential biomarkers for SCD risk stratification in CKD.

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