Related Experiment Video

Updated: Jan 14, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

1.0K

Metabolomics of Sepsis and Acute Kidney Injury in Infants and Children: Current Challenges in Prevention, Diagnosis,

Vanda Koko1, Vy Nguyen1, Sean N Avedissian2

  • 1Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, CA, 92093-0657, USA.

Infectious Diseases and Therapy
|October 16, 2025
PubMed

Insights

Metabolomics aids in diagnosing sepsis and acute kidney injury (AKI) in children by identifying biomarkers. This approach can improve drug therapy and patient outcomes, though more research is needed for clinical use.

Area of Science:

  • Biochemistry
  • Pediatric Medicine
  • Clinical Diagnostics

Background:

  • Sepsis and acute kidney injury (AKI) are major causes of illness and death in children.
  • Diagnosing sepsis and AKI in pediatric populations presents significant challenges.

Purpose of the Study:

  • To review the application of metabolomics in diagnosing sepsis and AKI in neonates, infants, and children.
  • To explore the role of metabolomic profiling in identifying disease biomarkers and optimizing drug therapy.
  • To address challenges in translating metabolomic research into clinical practice.

Main Methods:

  • Comprehensive literature review of metabolomics applications in pediatric sepsis and AKI.
  • Analysis of studies on metabolomic profiling for biomarker discovery.
  • Examination of pharmacometabolomics for drug therapy optimization.

Main Results:

  • Metabolomic profiling can accurately identify biomarkers for sepsis and AKI, enabling early detection and prevention.
  • Pharmacometabolomics offers potential for tailoring drug therapy by predicting pharmacokinetic profiles.
  • Significant obstacles exist, including the need for standardized methods, age-specific data, and large-scale validation.

Conclusions:

  • Metabolomics holds promise for improving the diagnosis and treatment of sepsis-associated AKI in children.
  • Further research and standardization are crucial for integrating metabolomics into clinical practice.
  • Metabolomics-driven guidelines can lead to better clinical outcomes for affected pediatric patients.

Keywords:
Acute kidney injuryMetabolomicsNeonatesPediatricsPharmacometabolomicsSepsis

More Related Videos

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury07:03

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury

Published on: February 15, 2022

1.7K
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

6.9K

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
257
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
564
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
876
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
191
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
810
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
295