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Optimizing Antiviral Stockpiles for Pandemic Response: A Strategic Framework
1Bright Global Health, Waterford, Virginia, USA.
The Journal of Infectious Diseases
|October 16, 2025
Summary
Pandemic preparedness requires updated influenza antiviral stockpiling strategies. Lessons from past pandemics and new technologies can improve supply chain resilience and drug deployment for future health crises.
Area of Science:
- Public Health
- Infectious Diseases
- Pharmacology
Background:
- Influenza antiviral stockpiling is crucial for pandemic preparedness.
- Past pandemics (e.g., 2009 H1N1, COVID-19) highlight the need for effective strategies.
- Current stockpiles aim for 25% US population coverage, informed by economic modeling and experience.
Purpose of the Study:
- To examine the evolution of antiviral stockpiling strategies for influenza.
- To identify lessons learned from recent pandemics and current challenges.
- To propose a framework for optimizing antiviral stockpiles.
Main Methods:
- Review of historical pandemic responses and current stockpiling practices.
- Analysis of challenges including supply chain, resistance, and deployment.
- Exploration of emerging antiviral classes and technologies (AI, manufacturing).
Main Results:
- Increasing antiviral diversity presents both opportunities and complexities.
- Advances in AI and manufacturing offer potential for just-in-time production.
- Integration of diagnostics and streamlined distribution can transform stockpiling.
Conclusions:
- Optimizing antiviral stockpiles requires balancing immediate response with long-term strategy.
- Addressing resistance management, pediatric formulations, and supply chain resilience is critical.
- Novel therapeutics and technologies can enhance future pandemic preparedness.
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