Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Aberrant Proliferation and Cell Fate Underlie Oral Defects in a Mouse Model of EvC Syndrome.

Journal of dental research·2026

Same author

Analysis of Eya1 and Tbx1 mutants highlights interactions between the muscle and developing cartilage during external ear formation.

Development (Cambridge, England)·2026

Same author

Tooth-bone attachment tissue is produced by cells with a mixture of odontoblastic and osteoblastic features in reptiles.

Journal of anatomy·2025

Same author

Mapping the murine TMJ glenoid fossa over development, homeostasis and in response to disease.

Journal of anatomy·2025

Same author

The wide gape of snakes: A comparison of the developing mandibular symphysis in sauropsids.

Journal of anatomy·2025

Same author

A suture in time: The ontogeny of cranial suture morphology in mammals.

Journal of anatomy·2025

Same journal

Gold Nanoparticles Enhance the Antibacterial and Osteogenic Properties of Polyetheretherketone.

Journal of dental research·2026

Same journal

Periodontitis-Aggravated Diabetic Kidney Disease with Altered Glycolysis.

Journal of dental research·2026

Same journal

Response to Letter to Editor: "Estimating the Individualized Effect of Tooth Extraction before Radiotherapy on Osteoradionecrosis Using Causal Machine Learning".

Journal of dental research·2026

Same journal

Reorienting Oral Health Promotion through Systems Thinking.

Journal of dental research·2026

Same journal

<i>Porphyromonas gingivalis</i>-Induced NETs Mediate Neuroinflammation via TLR4 Activation.

Journal of dental research·2026

Same journal

Oral Burden of Sjögren Disease: A Systematic Review and Meta-analysis.

Journal of dental research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 14, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Activating Endogenous Condylar Stem Cells to Enhance TMJ Repair.

T Tuwatnawanit^1,2, N Anthwal¹, A S Tucker¹

¹Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK.

Journal of Dental Research

|October 17, 2025

Summary

This summary is machine-generated.

Regenerative therapies for temporomandibular joint disorders (TMDs) are advancing by targeting fibrocartilage stem/progenitor cells (FCSCs). Stimulating these cells via signaling pathways enhances TMJ repair in animal models.

Keywords:

fibrocartilage osteoarthritis regeneration signal pathways stem cell niche temporomandibular joint disorders

More Related Videos

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

Published on: January 11, 2018

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

Related Experiment Videos

Last Updated: Jan 14, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

Published on: January 11, 2018

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

Area of Science:

Biomedical Engineering
Regenerative Medicine
Stem Cell Biology

Background:

Temporomandibular joint disorders (TMDs) significantly impact quality of life due to the TMJ's limited self-repair capacity.
Fibrocartilage stem/progenitor cells (FCSCs) in the condyle are key targets for TMJ regeneration.
Signaling pathways (Wnt, Hedgehog, Notch) regulate FCSC behavior and TMJ development.

Purpose of the Study:

To explore regenerative strategies for TMJ disorders by targeting FCSCs.
To investigate the role of signaling pathways in TMJ regeneration.
To develop novel therapeutic approaches for TMJ repair.

Main Methods:

In vivo lineage tracing of condylar FCSCs in animal models.
Manipulation of key signaling pathways (Wnt, Hedgehog, Notch) to stimulate endogenous stem cells.
Combination of signaling pathway modulation with bioengineering techniques, including scaffold development.

Main Results:

Identification of FCSC subpopulations and niche-supporting cells in the TMJ condyle.
Demonstrated enhancement of TMJ regenerative capacity in various animal models (mouse, rat, rabbit, porcine) through pathway stimulation.
Successful integration of bioengineering scaffolds for controlled delivery of pathway modulators.

Conclusions:

Targeting TMJ FCSCs and their associated signaling pathways offers a promising avenue for regenerative therapies.
Advanced bioengineering combined with pathway manipulation can promote true regeneration of TMJ structures.
Hydrogel-based injectable therapies are emerging as novel approaches for TMJ repair and symptom alleviation.