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Copeptin as a promising biomarker of cerebrovascular events: A minireview
Kamila Smolikova1,2, Pavel Potuznik1,2, Marek Peterka1,2
1Department of Neurology, University Hospital Pilsen, Pilsen, Czech Republic.
Insights
Copeptin shows potential as a biomarker for predicting cerebrovascular events and stroke severity. This peptide may aid in early prediction and prevention strategies for these critical health issues.
Area of Science:
- Biomarkers
- Neurology
- Endocrinology
Background:
- Cerebrovascular events represent a significant global health challenge.
- Despite advances, high morbidity and mortality necessitate improved prevention and early prediction.
- Biomarker identification is crucial for enhancing patient outcomes.
Purpose of the Study:
- To review the role of copeptin as a potential biomarker for cerebrovascular events.
- To explore copeptin's diagnostic and prognostic capabilities in neurological conditions.
- To assess copeptin's utility in emergency care settings.
Main Methods:
- Review of selected studies on copeptin and cerebrovascular events.
- Analysis of copeptin's correlation with stroke severity and radiological impairment.
- Investigation of copeptin's predictive value for cerebrovascular event recurrence.
Main Results:
- Copeptin levels correlate with the severity of clinical and radiological impairment post-stroke.
- Copeptin demonstrates potential for predicting cerebrovascular event recurrence within 90 days of transient ischemic attack.
- Copeptin offers advantages in emergency care due to rapid determination compared to other markers.
Conclusions:
- Copeptin is a promising biomarker for the diagnosis and prognosis of cerebrovascular events.
- Understanding copeptin's clinical applications is vital for advancing stroke care.
- Limitations exist, influenced by vascular risk factors, necessitating further research.
Abstract:
Cerebrovascular events remain a major health issue, and despite significant improvements in diagnosis and treatment in recent years, their high morbidity and mortality mean that increasing attention is now being given to prevention and early prediction. One option for achieving this is to examine various biomarkers. This mini review covers copeptin, a 39-amino-acid glycopeptide, derived from the precursor protein pre-provasopressin. Copeptin shows great potential in the diagnosis and prognosis of diverse diseases, including cerebrovascular events. Compared to arginine vasopressin or cortisol alone, it shows better potential for use in emergency care due to its rapid determination. Understanding the role of copeptin and its clinical applications is essential for advancing patient care and treatment strategies. This mini review presents selected studies on the use of copeptin as a potential biomarker for cerebrovascular events. Its level correlates with the severity of both clinical and radiological impairment after a stroke. A correlation has been demonstrated between copeptin levels and the ability to predict a cerebrovascular event recurrence within 90 days after a transient ischemic attack. This mini review also includes the limits to copeptin, which are influenced by selected vascular risk factors for cerebrovascular events.
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