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Developing a Discrete Choice Experiment Instrument for Evaluating Patients' Preferences in Precision Oncology.

Zahra Karimi Majd1, Nazila Yousefi1, Mohammad Peikanpour1

  • 1Department of Pharmacoeconomics and Pharma Management, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Iranian Journal of Pharmaceutical Research : IJPR
|October 17, 2025
PubMed
Summary

Patient preferences for precision oncology are crucial. A validated instrument identified key factors like treatment access, costs, life expectancy gains, and quality of life improvements for personalized medicine.

Keywords:
CancerDiscrete Choice ExperimentPatients’ PreferencesPrecision MedicinePrecision OncologyPreference Measurement Tool

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Area of Science:

  • Oncology
  • Health Economics
  • Patient-Centered Care

Background:

  • Patient preferences are vital for evaluating precision medicine (PM) interventions alongside clinical and technical factors.
  • Understanding patient priorities is key to successful implementation of personalized oncology.

Purpose of the Study:

  • To identify and prioritize patient-important attributes in precision oncology.
  • To develop and validate a standardized stated preference instrument for assessing patient preferences in precision oncology.

Main Methods:

  • Systematic literature review to extract key attributes of precision oncology.
  • Delphi method with 35 experts using a Likert scale questionnaire for attribute prioritization.
  • Development and validation of a discrete choice experiment (DCE) instrument based on prioritized attributes.

Main Results:

  • A consensus-based DCE instrument was developed, including four attributes and 14 levels.
  • Key attributes identified: treatment accessibility, out-of-pocket expenditures, changes in life expectancy, and changes in quality of life.
  • The instrument provides a robust measure for evaluating patient preferences in precision oncology.

Conclusions:

  • The developed DCE questionnaire reflects the main preferences of Iranian experts regarding precision oncology.
  • This validated instrument can be utilized to assess patient preferences and willingness to pay (WTP) in precision oncology settings.