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Updated: Jan 14, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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Advances in the Drug Delivery Systems for Psoriasis Topical Therapy
Yang Liu1, Ruizhen Chang2, Huan Deng2
1Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, People's Republic of China.
International Journal of Nanomedicine
|October 17, 2025
Summary
Topical delivery systems offer improved psoriasis (PSO) treatment by enhancing drug stability and skin penetration. These advanced systems aim to overcome the limitations of traditional PSO therapies, providing new therapeutic avenues.
Area of Science:
- Dermatology
- Pharmaceutics
- Biotechnology
Background:
- Psoriasis (PSO) is a chronic immune-related skin disease characterized by rapid skin cell proliferation, leading to plaque formation.
- Current PSO treatments, including anti-inflammatory drugs and immunosuppressants, often suffer from poor targeting, low bioavailability, and significant side effects.
- Topical drug delivery systems are emerging as a promising strategy to enhance PSO treatment efficacy and patient outcomes.
Purpose of the Study:
- To review the recent advancements in topical delivery systems for psoriasis treatment.
- To summarize the development status and clinical application of various delivery systems for PSO therapy.
- To provide insights for designing novel topical delivery systems to improve psoriasis management.
Main Methods:
- Comprehensive literature review of various topical delivery systems for psoriasis.
- Analysis of nanoparticles, hydrogels, microneedles, micelles, dendrimers, liposomes, nanoemulsions, and vesicles.
- Summary of the development and clinical status of these delivery systems in psoriasis treatment.
Main Results:
- Topical delivery systems demonstrate potential in improving drug stability, skin penetration, and therapeutic efficacy for psoriasis.
- A wide range of delivery systems, including nanoparticles and liposomes, are being investigated for enhanced PSO topical therapy.
- The review highlights the progress and ongoing research in applying these systems to clinical psoriasis treatment.
Conclusions:
- Multifunctional topical delivery systems offer innovative therapeutic strategies for psoriasis.
- These systems can overcome the limitations of conventional psoriasis treatments, reducing patient burden.
- Further development of novel topical delivery systems is crucial for advancing psoriasis therapy and management.
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