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Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...

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Related Experiment Video

Updated: Jan 14, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

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Published on: March 14, 2017

Improved Preprocedure Hematocrit in Chronic RBC Exchange Patients Following Splenectomy: A Case Report.

Aswath P Chandrasekar^1,2, Scott A Koepsell¹, Shelly M Williams¹

¹Department of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Case Reports in Hematology

|October 17, 2025

Summary

Splenectomy improved red blood cell (RBC) survival in patients undergoing chronic RBC exchange (RCE) for sickle cell disease and beta thalassemia. This led to higher hematocrit levels and more effective RCE therapy.

Area of Science:

Hematology
Transfusion Medicine
Surgical Oncology

Background:

Chronic RBC exchange (RCE) is vital for managing sickle cell disease and beta thalassemia.

Keywords:

apheresis beta thalassemia isovolemic hemodilution red cell exchange sickle cell disease splenectomy transfusion refractoriness

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Some patients experience accelerated loss of transfused RBCs, often linked to splenomegaly, hindering effective RCE.

Suboptimal RCE due to low pre-procedure hematocrit (HCT) necessitates alternative strategies.