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Trichosporon Urinary Tract Infections: A Hidden Menace Revealed.
Ahmad Elmimoghaddam1, Mahmoud Vahidi1,2, Reza Heidari1,3
1Medical Biotechnology Research Center, AJA University of Medical Sciences, Tehran, Iran.
Iranian Journal of Pathology
|October 17, 2025
Summary
Urinary tract infections (UTIs) caused by Trichosporon species, particularly Trichosporon asahii, are a growing concern in immunocompromised patients. Voriconazole shows the best in vitro activity against these fungal UTIs.
Area of Science:
- Mycology
- Infectious Diseases
- Clinical Microbiology
Background:
- Urinary tract infections (UTIs) caused by fungi, specifically Trichosporon species, pose a significant threat to hospitalized individuals and those with compromised immune systems.
- Accurate identification and understanding of antifungal susceptibility are crucial for effective management.
Purpose of the Study:
- To provide a comprehensive review of Trichosporon-induced UTIs, covering epidemiology, risk factors, diagnostics, and drug resistance.
- To highlight the predominant species and serotype responsible for these infections and evaluate current treatment strategies.
Main Methods:
- A narrative review methodology was employed, involving a thorough search of international scientific databases.
- Relevant studies focusing on Trichosporon UTIs, their causative agents, risk factors, diagnostic methods, and antifungal susceptibility were analyzed.
Main Results:
- Trichosporon asahii, particularly the G1 type, is identified as the primary cause of Trichosporon UTIs.
- Prolonged hospitalization and immunosuppressive therapy are key risk factors.
- Voriconazole exhibits potent in vitro activity against T. asahii, whereas amphotericin B and echinocandins show limited efficacy.
Conclusions:
- Accurate identification of Trichosporon species, utilizing advanced techniques like MALDI-TOF MS and DNA sequencing, is vital for optimal patient care.
- Voriconazole is a promising therapeutic option for Trichosporon UTIs, necessitating further clinical investigation.
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