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Molecularly imprinted polymer/CdTe quantum dots-decorated polymer optic fiber microprobes for Amoxicillin detection
Jianfeng Liang1, Qixuan Wu1, Ran Xiao1
1School of Materials Science and Engineering, Nanotechnology Research Center, Guangdong Engineering Technology Research Centre for Functional Biomaterials, State Key Laboratory of Optoelectronic Materials and Technologies, Sun Yat-sen University, Guangzhou, China.
Frontiers in Bioengineering and Biotechnology
|October 17, 2025
Summary
A new polymer optical fiber microprobe sensor accurately detects amoxicillin (AMX) residues. This residue-free sensor offers a sensitive and specific method for monitoring AMX in food and environmental samples.
Area of Science:
- Analytical Chemistry
- Materials Science
- Biomedical Engineering
Background:
- Amoxicillin (AMX) residues in food and environment pose public health risks, necessitating precise monitoring.
- Conventional fluorescence probes for AMX detection have limitations including poor specificity, safety concerns, and difficulty in in situ monitoring.
- Molecularly imprinted polymers (MIPs) and quantum dots (QDs) offer potential for developing advanced sensing materials.
Purpose of the Study:
- To develop a novel, sensitive, and specific sensor for detecting amoxicillin (AMX) residues.
- To overcome the limitations of existing fluorescence-based detection methods for AMX.
- To enable in situ and residue-free monitoring of AMX in biological and environmental samples.
Main Methods:
- Fabrication of a polymer optical fiber microprobe (POF MP) decorated with molecularly imprinted polymer (MIP) and CdTe quantum dots (QDs).
- Utilizing fluorescence spectroscopy for the detection of AMX based on the MIP/CdTe QD composite.
- Characterization of the sensor's performance, including detection range, limit of detection, specificity, and reusability.
Main Results:
- The developed MIP/CdTe QD-decorated POF MP sensor demonstrated high specificity and stability for AMX detection.
- The sensor achieved a linear detection range of 0.5–50 μg/L with a low limit of detection (LOD) of 0.31 μg/L.
- The sensor exhibited excellent biocompatibility, safety, and enabled residue-free, in situ monitoring.
Conclusions:
- The novel MIP/CdTe QD-decorated POF MP sensor provides a promising and innovative solution for precise AMX monitoring.
- This sensor addresses key limitations of conventional methods, offering advantages in specificity, reusability, and safety.
- The technology has significant potential for applications in microenvironmental monitoring, pharmaceutical sensing, and biomedical therapeutics.
