Related Experiment Video

Updated: Jan 14, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

5.8K

Recent innovations and challenges in the treatment of fungal infections

Di Liu1, Renjie Zhou1, Xindi Gao1

  • 1Department of Emergency, Xinqiao Hospital, Army Medical University, Chongqing, China.

Frontiers in Cellular and Infection Microbiology
|October 17, 2025
PubMed

Insights

Rising fungal infections and drug resistance necessitate novel antifungal therapies. This review explores innovative strategies, including combination treatments and biotechnological approaches, to combat "super fungi" like Candida auris.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Increasing prevalence of fungal infections, especially in immunocompromised populations.
  • Emergence of drug-resistant fungal strains, including WHO-designated "super fungi" like Candida auris.
  • Limitations of current antifungal agents (azoles, polyenes) due to resistance, toxicity, and selectivity issues.

Purpose of the Study:

  • To review recent advancements in antifungal drug development.
  • To outline future directions for novel antifungal therapies.
  • To address the urgent need for effective treatments against resistant fungal pathogens.

Main Methods:

  • Literature review of current research trends in antifungal therapy.
  • Analysis of emerging strategies such as multi-mechanistic combination therapies.
  • Evaluation of biotechnology-driven approaches for antifungal drug development.

Main Results:

  • Identification of multi-mechanistic combination therapies as a promising strategy.
  • Highlighting the potential of biotechnology-driven approaches in overcoming resistance.
  • Summarizing key challenges and opportunities in the field.

Conclusions:

  • Novel antifungal therapies are urgently required due to rising infections and resistance.
  • Combination therapies and biotechnological innovations show significant potential for future treatments.
  • Continued research and development are crucial for combating global fungal threats.
Keywords:
antifungal drugsbiotechnology-driven approachescombination therapydrug developmentfungal infections

More Related Videos

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

7.4K
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

14.2K

Related Concept Videos

Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
417
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
936
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
6.7K
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
496
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
239
Overview of Fungi01:29

Overview of Fungi

Fungi are a diverse group of eukaryotes more closely related to animals than other eukaryotes. Fungal cell walls comprise chitin, a polysaccharide that provides structural strength, and glucans, which contribute to flexibility and integrity. Other polysaccharides, such as mannans and galactosans, may supplement or replace chitin in some fungi. These adaptations, along with their preference for acidic environments and tolerance for high osmotic pressure, enable fungi to thrive in various...
1.6K