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Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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Schisanhenol Alleviates Mycophenolic Acid-Induced Intestinal Epithelial Cell Barrier Damage by Activating the
Yiyun Deng1,2,3, Jiawang Fan3, Chunlan Yang4
1Department of Pharmacy, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Iranian Journal of Pharmaceutical Research : IJPR
|October 17, 2025
Summary
Schisanhenol protects the intestinal barrier from damage by reducing cell death and restoring tight junctions. This natural compound works by activating antioxidant pathways, offering a potential therapeutic strategy.
Area of Science:
- Gastroenterology
- Pharmacology
- Cell Biology
Background:
- Mycophenolic acid (MPA) disrupts intestinal barrier function by inducing apoptosis and tight junction (TJ) loss.
- No effective treatments currently exist for MPA-induced intestinal damage.
- Schisanhenol (Sal), derived from traditional Chinese medicine, possesses potent antioxidant properties.
Purpose of the Study:
- To evaluate Schisanhenol's protective effects against MPA-induced intestinal barrier damage.
- To elucidate the underlying mechanisms of Sal's protective action.
Main Methods:
- Caco-2 cells were treated with MPA, Sal, or ML385.
- Cell viability, apoptosis, TJ protein expression, ROS levels, and oxidative/antioxidative biomarkers were assessed.
Main Results:
- Sal significantly enhanced cell viability and reduced apoptosis in MPA-treated cells.
- Sal upregulated TJ proteins (ZO-1, occludin) and modulated Nrf2/HO-1 expression.
- Sal decreased intracellular ROS and increased antioxidant levels (SOD, CAT, GSH).
Conclusions:
- Schisanhenol effectively alleviates MPA-induced intestinal barrier damage.
- Sal's protective effects are mediated through the Nrf2 signaling pathway, showcasing its antioxidant and antiapoptotic capabilities.
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