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Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Skeleton and Calcium Homeostasis01:21

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Essential Minerals for Bone Health01:31

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
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EndoCompass project: research roadmap for calcium and bone endocrinology.

Katharina Jähn-Rickert1,2, Karin Zibar Tomšić3, Athanasios D Anastasilakis4

  • 1Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 22529 Hamburg, Germany.

European Journal of Endocrinology
|October 17, 2025
PubMed
Summary

Endocrine research funding in Europe is insufficient. The EndoCompass project identified key priorities in metabolic bone diseases, including osteoporosis and rare disorders, to guide future research and investment.

Keywords:
bonebone mass acquisitionbone mineralizationbone qualitycalciumcellular senescencediagnostic technologieshypoparathyroidismhypophosphataemiainactivating PTH/PTHrP signalling disordersosteocytesosteoporosisparathyroid hormonephosphateprimary hyperparathyroidismskeletal dysplasiatargeted treatmentsvitamin D

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Area of Science:

  • Endocrinology and metabolic bone disease research.

Background:

  • Endocrine science is underrepresented in EU research funding despite its importance for human health.
  • A gap exists between the societal impact of endocrine disorders and their research prioritization.
  • The EndoCompass project aims to define strategic research priorities in endocrine science.

Purpose of the Study:

  • To identify and promote strategic research priorities in endocrine science.
  • To address critical hormone-related health challenges.
  • To provide a roadmap for research investment in metabolic bone diseases.

Main Methods:

  • Analysis of the EU CORDIS database (Horizon 2020).
  • Expert consultation in bone and calcium endocrinology.
  • Stakeholder engagement with society members and patient groups.

Main Results:

  • Priorities include primary hyperparathyroidism, chronic hypoparathyroidism, and rare calcium-phosphate disorders.
  • Key research areas: bone as an endocrine organ, bone mass, osteoporosis, skeletal dysplasias.
  • Emphasis on cellular senescence, sex-specific differences, and diagnostic tools for bone quality.

Conclusions:

  • An evidence-based roadmap for strategic research investment in metabolic bone diseases.
  • Identifies crucial areas for pathophysiology, prevention, and treatment.
  • Supports aligning research funding with high-impact endocrine health areas.