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EndoCompass project: research roadmap for calcium and bone endocrinology
Katharina Jähn-Rickert1,2, Karin Zibar Tomšić3, Athanasios D Anastasilakis4
1Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 22529 Hamburg, Germany.
European Journal of Endocrinology
|October 17, 2025
Summary
Endocrine research funding in Europe is insufficient. The EndoCompass project identified key priorities in metabolic bone diseases, including osteoporosis and rare disorders, to guide future research and investment.
Area of Science:
- Endocrinology and metabolic bone disease research.
Background:
- Endocrine science is underrepresented in EU research funding despite its importance for human health.
- A gap exists between the societal impact of endocrine disorders and their research prioritization.
- The EndoCompass project aims to define strategic research priorities in endocrine science.
Purpose of the Study:
- To identify and promote strategic research priorities in endocrine science.
- To address critical hormone-related health challenges.
- To provide a roadmap for research investment in metabolic bone diseases.
Main Methods:
- Analysis of the EU CORDIS database (Horizon 2020).
- Expert consultation in bone and calcium endocrinology.
- Stakeholder engagement with society members and patient groups.
Main Results:
- Priorities include primary hyperparathyroidism, chronic hypoparathyroidism, and rare calcium-phosphate disorders.
- Key research areas: bone as an endocrine organ, bone mass, osteoporosis, skeletal dysplasias.
- Emphasis on cellular senescence, sex-specific differences, and diagnostic tools for bone quality.
Conclusions:
- An evidence-based roadmap for strategic research investment in metabolic bone diseases.
- Identifies crucial areas for pathophysiology, prevention, and treatment.
- Supports aligning research funding with high-impact endocrine health areas.
Keywords:
bonebone mass acquisitionbone mineralizationbone qualitycalciumcellular senescencediagnostic technologieshypoparathyroidismhypophosphataemiainactivating PTH/PTHrP signalling disordersosteocytesosteoporosisparathyroid hormonephosphateprimary hyperparathyroidismskeletal dysplasiatargeted treatmentsvitamin DMore Related Videos
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