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EndoCompass project: research roadmap for reproductive and developmental endocrinology
Martine Cools1,2, Csilla Krausz3,4, Anders Juul5,6
1Department of Internal Medicine and Paediatrics, Ghent University.
European Journal of Endocrinology
|October 17, 2025
Summary
Endocrine research funding in Europe is insufficient. The EndoCompass project identified key priorities in reproductive and developmental endocrinology to guide future research and reduce the burden of hormone-related disorders.
Area of Science:
- Reproductive and developmental endocrinology
- Hormone health
- Endocrine disorders
Background:
- Endocrine science is underrepresented in EU research programs, despite its importance for human wellbeing.
- A gap exists between the societal impact of endocrine disorders and their research prioritization.
- The EndoCompass project aims to identify strategic research priorities in endocrine science.
Purpose of the Study:
- To identify and promote strategic research priorities in endocrine science.
- To address critical hormone-related health challenges.
- To provide a roadmap for strategic research investment in endocrinology.
Main Methods:
- Analysis of the EU CORDIS database (Horizon 2020 framework).
- Expert consultation to identify key research priorities.
- Stakeholder engagement, including society members and patient advocacy groups.
Main Results:
- Priorities include variations in sex development, hypothalamic-pituitary-gonadal regulation, and reproductive disorders.
- Key areas involve improving diagnostics (e.g., (epi)genetic analysis), optimizing hormonal treatments, and fertility preservation.
- Emphasis on pan-European registries, novel reproductive technologies, and environmental impacts on reproductive health.
Conclusions:
- An evidence-based roadmap for strategic research investment in reproductive and developmental endocrinology.
- Identifies crucial areas for investigation into pathophysiology, prevention, and treatment.
- Aims to reduce the burden of endocrine disorders on individuals and society.
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