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First 1000 Days Strategies to Prevent Childhood Obesity: A Narrative Review and Recommendations From the EndObesity

Mireille C Schipper1,2, Anna Manshanden3, Kaat Philippe4

  • 1The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Pediatric Obesity
|October 17, 2025
PubMed

Insights

Preventing childhood obesity is crucial. Focusing on family health behaviors during the first 1000 days (from preconception to age 2) offers a key window for effective intervention strategies.

Area of Science:

  • Public Health
  • Pediatrics
  • Nutritional Science

Background:

  • Childhood obesity is a significant global health issue with severe consequences.
  • Early intervention is critical, with the first 1000 days of life identified as a key period for prevention.
  • The EndObesity Consortium prioritizes strategies within this crucial developmental window.

Purpose of the Study:

  • To synthesize findings from the EndObesity Consortium regarding childhood obesity prevention.
  • To review evidence on family health behaviors in the first 1000 days and their impact on offspring obesity risk.
  • To explore prediction models and intervention strategies for preventing childhood obesity.

Main Methods:

  • This is a narrative review synthesizing evidence from large multi-cohort studies.
  • The review focuses on data related to the first 1000 days of life (preconception to 2 years).
  • Findings from the Horizon2020 EU-funded JPI Consortium EndObesity are summarized.

Main Results:

  • Family-based health behaviors during the first 1000 days significantly influence offspring obesity risk.
  • Childhood obesity prediction models show potential for use within the first 1000 days.
  • Evidence supports enhancing prenatal and postnatal interventions to curb obesity development.

Conclusions:

  • The first 1000 days represent a critical window for childhood obesity prevention.
  • Integrated strategies encompassing research, practice, and policy are needed.
  • Addressing the multifaceted challenges of childhood obesity requires a comprehensive approach starting from preconception.

Keywords:
childhood obesityeuropean consortiumfirst 1000 days of lifelifestylepredictionprevention

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