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Multimodal Shortwave Infrared Imaging for Visualization of Injection Laryngoplasty.

Roy K Park1, Melissa C Lee1, Simon Härtl2,3,4,5,6

  • 1Department of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|October 17, 2025
PubMed
Summary
This summary is machine-generated.

Shortwave infrared (SWIR) imaging improves visualization of injection laryngoplasty fillers. This technique enhances surgical precision by enabling accurate localization of injected materials in the larynx, paving the way for advanced surgical methods.

Keywords:
fluorescencelabel‐free imaginglaryngeal surgerynear infraredshortwave infrared

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Area of Science:

  • Laryngology
  • Medical Imaging
  • Biomedical Optics

Background:

  • Accurate filler placement is crucial for injection laryngoplasty.
  • Visible light spectrum imaging presents limitations in visualizing laryngeal structures and injected fillers.
  • Shortwave infrared (SWIR) wavelengths offer enhanced penetration and reduced scattering for improved visualization.

Purpose of the Study:

  • To perform multispectral characterization of the larynx in the SWIR range.
  • To demonstrate accurate visualization of injection laryngoplasty using SWIR imaging techniques.

Main Methods:

  • Utilized a custom SWIR imaging system for multispectral imaging of porcine and human larynges at various wavelengths (1050-1650 nm).
  • Performed injection laryngoplasty with common agents (saline, carboxymethylcellulose gel, calcium hydroxyapatite sphere suspension).
  • Employed SWIR reflection and fluorescence imaging modalities for material visualization.

Main Results:

  • SWIR imaging at 1550 nm significantly increased contrast between vocal fold epithelium and respiratory mucosa compared to visible light.
  • Successfully visualized and localized saline and carboxymethylcellulose gel injections at 1550 nm.
  • Demonstrated SWIR fluorescence properties of calcium hydroxyapatite for material localization during injection.

Conclusions:

  • Multimodal SWIR imaging enables accurate visualization of filler materials during injection laryngoplasty.
  • This novel technique facilitates precision-guided surgical approaches in laryngology.