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Updated: Jan 6, 2026
Size Matters: Measurement of Capsule Diameter in Cryptococcus neoformans
Published on: February 27, 2018
Analysis of clinical characteristics and prognostic factors in AIDS complicated by cryptococcal meningitis
Yanlan Liang1,2,3, Xiyang Dong4, Yong Deng5
1Department of Infection Diseases, Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian province, Fujian Medical University Affiliated First Quanzhou Hospital, No. 250 East Street, Licheng District, Quanzhou, 362000, Fujian, China.
Objective:
To analyze clinical features and identify prognostic factors in HIV/AIDS patients with cryptococcal meningitis (CM), and to develop a predictive model for short-term mortality.
Methods:
A multicenter retrospective study was conducted on 197 HIV/AIDS patients diagnosed with CM from 2013 to 2023. Clinical data were collected, and multivariate logistic regression was used to construct a prognostic model.
Results:
The median age was 48 years (IQR: 33-57.5), with 75.6% males. Common symptoms included headache (68.5%), fever (52.8%), and nausea/vomiting (49.2%). Independent risk factors for mortality were consciousness disturbance (OR = 7.785, P = 0.013) and elevated intracranial pressure (OR = 1.011, P = 0.023), while CD8+T lymphocytes (OR = 0.997, P = 0.022) and platelet count (OR = 0.990, P = 0.014) were protective. The prognostic model (AUC = 0.860, 95% CI: 0.776-0.943) demonstrated sensitivity of 71.4% and specificity of 89.3%.
Conclusion:
Consciousness disturbance, intracranial pressure, CD8+ T cells, and platelets independently predict mortality in HIV/AIDS-associated CM. Early intervention targeting these factors may improve outcomes.
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