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Patient and Clinician Views on Risk Prediction for Chemotherapy-Induced Peripheral Neuropathy.

Katherine J Holzer1, Simon Haroutounian1, Lesley A Colvin2

  • 1Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA.

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|October 17, 2025
PubMed
Summary

Predicting chemotherapy-induced peripheral neuropathy (CIPN) from oxaliplatin is crucial for colorectal cancer patients. Understanding patient and clinician views highlights the need for tools to manage this debilitating side effect and improve treatment outcomes.

Keywords:
Chemotherapy-induced peripheral neuropathyclinician decision-makingcolorectal canceroxaliplatinpatient perspectivesrisk prediction

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Area of Science:

  • Oncology
  • Neuroscience
  • Patient-Reported Outcomes

Background:

  • Oxaliplatin is a key chemotherapy for colorectal cancer.
  • Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and severe side effect.
  • CIPN significantly impairs patient quality of life and necessitates treatment changes.

Purpose of the Study:

  • To explore patient and clinician perspectives on CIPN risk.
  • To understand the impact of CIPN on treatment and daily life.
  • To assess the perceived value of CIPN risk prediction tools.

Main Methods:

  • Semi-structured interviews with six colorectal cancer patients treated with oxaliplatin.
  • Interviews with six clinicians (four oncologists, two nurse practitioners).
  • Thematic analysis of interview data.

Main Results:

  • Clinicians view neuropathy as oxaliplatin's most concerning side effect, often requiring dose reduction.
  • Patients experience sensory issues, functional deficits, and lifestyle disruptions due to CIPN.
  • Both patients and clinicians strongly desire validated tools for predicting CIPN risk.

Conclusions:

  • CIPN risk prediction holds potential for proactive management and improved treatment decisions.
  • Clinicians emphasize the need for accurate, actionable, and integrated risk prediction tools.
  • Balancing treatment efficacy with quality of life is essential when managing CIPN.