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Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation
Published on: June 5, 2012
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Glomerulopathy associated with schistosomiasis mansoni
Irma Bandeira de Sousa Pontes1, Amaro Nunes Duarte Neto2, Cristiane Bitencourt Dias1
1Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Laboratório de Fisiopatologia Renal, São Paulo, SP, Brazil.
Jornal Brasileiro De Nefrologia
|October 17, 2025
Summary
Schistosomiasis, a parasitic disease linked to poor sanitation, affects millions in Brazil. This review explores its impact on kidney health, focusing on glomerulopathy and uncertain pathogenic mechanisms for improved treatment strategies.
Area of Science:
- Nephrology
- Infectious Diseases
- Parasitology
Background:
- Schistosomiasis is a significant public health issue in Brazil, endemic in areas with poor sanitation.
- The kidney is a target organ, with schistosomiasis causing renal alterations, acute kidney injury, and glomerular diseases.
- Glomerulopathy affects 5-6% of patients with active schistosomiasis, rising to 15% in the hepatosplenic form.
Purpose of the Study:
- To review established knowledge on schistosomiasis-associated glomerular disease.
- To investigate the probable pathogenic mechanisms underlying these kidney complications.
- To stimulate discussion for developing enhanced therapeutic interventions.
Main Methods:
- Literature review of classic information on schistosomiasis and kidney disease.
- Exploration of proposed pathogenic mechanisms, including immune complex involvement.
- Analysis of treatment challenges and the potential need for immunosuppressive therapy.
Main Results:
- Membranoproliferative glomerulonephritis and focal segmental glomerulosclerosis are common histological findings.
- Immune complex deposition, potentially against schistosome antigens, is implicated in pathogenesis.
- Antiparasitic treatment alone may not halt chronic kidney disease progression.
Conclusions:
- The pathogenesis of schistosomiasis-induced glomerulopathy remains uncertain, complicating treatment.
- Further research into pathogenic mechanisms is crucial for advancing treatment options.
- The role of immunosuppressive therapy warrants consideration in managing chronic kidney disease in schistosomiasis patients.
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