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Updated: Jan 14, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
Published on: December 4, 2015
New twists in anti-malarial drug resistance
José Cubillán-Marín1, Tim W Gilberger1
1Centre for Structural Systems Biology, 22607 Hamburg, Germany; Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany; University of Hamburg, 20146 Hamburg, Germany.
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In this issue of Cell Chemical Biology, Bopp et al.1 discover that malaria parasite resistance to halofuginone is mediated by mutations in PfApiAT2, an amino acid transporter, rather than halofuginone's target prolyl-tRNA synthetase. This rapid and distinctive resistance mechanism highlights amino acid transport as a promising avenue for drug discovery.
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