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Updated: Jan 14, 2026

Visualization of Endoplasmic Reticulum Subdomains in Cultured Cells
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Tubular ER dysfunction in neurodegenerative diseases

Md Golam Sharoar1, Riqiang Yan2

  • 1Alzheimer's disease Research Program, Corewell Health Research Institute (CHRI), Corewell Health East, 3811 W 13 Mile Road, Royal Oak, MI 48073, United States of America; Department of Internal Medicine, Oakland University William Beaumont School of Medicine (OUWB), Corewell Health East, 3811 W 13 Mile Road, Royal Oak, MI 48073, United States of America.

Neurobiology of Disease
|October 17, 2025
PubMed
Summary

Endoplasmic reticulum (ER) tubule shaping proteins are crucial for neuronal health. Dysfunction in these proteins contributes to neurodegenerative diseases like Alzheimer's disease and hereditary spastic paraplegias.

Keywords:
Alzheimer's diseaseDystrophic neuriteHereditary spastic paraplegiaMitochondria dysfunctionTubular ER clusteringTubular endoplasmic reticulum

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