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Related Concept Videos

Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

260
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
260
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

368
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
368
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

173
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
173
Myocarditis IV: Nursing Management01:22

Myocarditis IV: Nursing Management

204
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
204
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

449
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
449
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

498
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
498

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Related Experiment Video

Updated: Jan 14, 2026

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
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Immune Checkpoint Inhibitor Myocarditis Masquerading as Brugada Syndrome.

Aleksandr Talishinsky1, Kinan Bachour2, Charlie Lin2

  • 1Department of Medicine, University of California at Los Angeles (UCLA), Los Angeles, California, USA.

JACC. Case Reports
|October 17, 2025
PubMed
Summary
This summary is machine-generated.

Immune checkpoint inhibitor (ICI)-associated myocarditis can mimic Brugada syndrome, presenting as a Brugada electrocardiographic (ECG) phenocopy. Early diagnosis and treatment of ICI myocarditis are crucial for patient outcomes.

Area of Science:

  • Cardio-oncology
  • Electrophysiology
  • Immunotherapy

Background:

  • Immune checkpoint inhibitors (ICIs) are novel cancer immunotherapies.
Keywords:
cancerchest painelectrocardiogramelectrophysiologyphenotype

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  • ICI-associated myocarditis is a rare but severe complication.
  • Brugada electrocardiographic (ECG) phenocopy is an uncommon presentation.