Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Determination

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations.

Nature genetics·2026

Same author

Social deprivation, race, and metabolic syndrome in patients with polycystic ovary syndrome.

Journal of the Endocrine Society·2026

Same author

Racial/ethnic variation in ovarian responsiveness and live birth after in vitro fertilization.

Fertility and sterility·2026

Same author

Responsible use of artificial intelligence in manuscript preparation: guidance from Fertility and Sterility.

Fertility and sterility·2026

Same author

Progestin IUDs and Ectopic Pregnancy - A Call for Context, Not Concern.

NEJM evidence·2025

Same author

Human embryo testing and phased validation: from innovation to practice.

Fertility and sterility·2025

Same journal

Uterus-Sparing Laparoscopic Reversal of Complete Non-Puerperal uterine Inversion: A rare Case and Challenging Procedure!

Fertility and sterility·2026

Same journal

Minimally Invasive, Fertility-Sparing Surgical Management of Multiple Bilateral Ovarian Dermoid Cysts.

Fertility and sterility·2026

Same journal

Preconception dietary patterns in association with live birth and pregnancy loss: a couples-based approach.

Fertility and sterility·2026

Same journal

Corrigendum to "Clinical management of mosaic results from preimplantation genetic testing for aneuploidy of blastocysts: a committee opinion" [Fertil Steril 2023;120:973-82].

Fertility and sterility·2026

Same journal

Expression of concern 'Adhesion formation after intracapsular myomectomy with or without adhesion barrier' [Fertil Steril 2011; 95:1780-5].

Fertility and sterility·2026

Same journal

Ovarian stimulation with follitropin δ is safe and effective: results from the RITA randomized, double-blind, placebo-controlled trials.

Fertility and sterility·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 14, 2026

Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound

Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound

Published on: March 4, 2015

Embryo viability: a case for finding the right words

Iris T Lee¹, Maureen G Phipps², Kurt T Barnhart¹

¹Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania.

Fertility and Sterility

|October 17, 2025

Summary

No abstract available in PubMed .

More Related Videos

Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts

Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts

Published on: March 2, 2017

Human Blastocyst Biopsy and Vitrification

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

Related Experiment Videos

Last Updated: Jan 14, 2026

Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound

Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound

Published on: March 4, 2015

Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts

Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts

Published on: March 2, 2017

Human Blastocyst Biopsy and Vitrification

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019