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Celiac Disease in Specific Populations

Isabel Hujoel1, James A King2, Amanda K Cartee3

  • 1Division of Gastroenterology, Department of Internal Medicine, University of Washington, 1410 NE Campus Parkway, Seattle, WA 98195, USA.

Gastrointestinal Endoscopy Clinics of North America
|October 17, 2025
PubMed

Insights

Celiac disease (CeD) affects diverse populations across all demographics and locations. Recognizing CeD

Area of Science:

  • Immunology
  • Gastroenterology
  • Genetics

Background:

  • Previous understanding of celiac disease (CeD) risk populations was limited.
  • CeD affects individuals irrespective of race, sex, age, socioeconomic status, or geography.
  • CeD is associated with autoimmune disorders, immune-mediated diseases, and chromosomal abnormalities.

Purpose of the Study:

  • To broaden the understanding of celiac disease risk populations.
  • To highlight the diverse associations and presentations of celiac disease.
  • To emphasize the need for personalized management strategies.

Main Methods:

  • Review of recent epidemiological data on celiac disease.
  • Analysis of comorbidities and genetic associations with celiac disease.
  • Synthesis of information on variations in disease presentation and management.

Main Results:

  • Celiac disease risk is not confined to specific demographics.
  • A wide range of autoimmune and genetic conditions are linked to celiac disease.
  • Significant variability exists in how celiac disease presents and is managed across different groups.

Conclusions:

  • Celiac disease has a broader at-risk population than previously recognized.
  • Understanding the heterogeneity of celiac disease is crucial for effective diagnosis and treatment.
  • Personalized approaches are essential for managing celiac disease in diverse patient groups.

Keywords:
AgeAutoimmune conditionsCeliac diseaseChromosomal abnormalitiesGenderRacial differenceSocioeconomic status

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